PS 210

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PS 210 是一种有效的、特异性的 PDK1 激活剂，靶向 PDK1 的 PIF 结合袋。

PS 210 is a potent, specific activator of PDK1 that target the PIF-binding pocket of PDK1, does not alter the activity of any of the 121 kinases (S6K, PKB/Akt or GSK3).

When PS210 induces a stabilization of PDK1 to the temperature gradien, PS210 stabilized the residue Arg131, located opposite to the helix a-B at the other extreme of the helix a-C. Thus, the residues forming part of the phosphate-binding site appear to be a fixed point that allows for the relative movement of the helices in the process of PDK1 activation.

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PS210

PI3K/Akt/mTOR signaling

PDK

PDK

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1221962-86-2

380.319

C19H15F3O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (262.94 mM)

O=C(O)C(C(C1=CC=CC=C1)CC(C2=CC=C(C(F)(F)F)C=C2)=O)C(O)=O

2-(3-oxo-1-phenyl-3-(4-(trifluoromethyl)phenyl)propyl)malonic acid

(-20℃)

With Ice Pack

≥ 2 years